Ex vivo research is a rapidly developing area with the potential to significantly impact a wide range of biomedical applications. Recent publications, in peer reviewed scientific journals, include the following applications.
Condition and Engineer Developing Tissues
"cell phenotype can be modulated in engineered blood vessels by applying selected combinations of biochemical and mechanical stimuli [6]"
"mechanical stimulation of tissue-cultured skeletal muscle cells cause changes similar to those seen when in vivo skeletal muscle is mechanically loaded [4]"
Reveal Fundamental Mechanisms of Cell Function
"3D culture systems....offer a powerful alternative way of screening large numbers of genes and associated processess in a setting that takes into account the critical interaction of cells with their neighbors and with their environment [2]"
Direct Stem Cell Differentiation
"mechanical cyclic stretch or fluid shear flow is capable of inducing MSC differentiation into the osteogenic lineage [1]"
"mechanical environment is important in maintaining differentiated phenotype of bone cells [5]"
Provide an in vitro testbed for drug development
"tissue like structures more realisitically model the structural architecture of differentiated function of breast cancer than a cellular monolayer providing in vivo like responses to therapeutic agents [3]"
Until recently, this research could not be conducted without extensive time and resources dedicated toward designing, fabricating, and validating home-built mechanical stimulation bioreactor devices. Today, TGT employs experts in mechanical, electrical, software and biomedical engineering to develop bioreactors so you don't have to.
We supply the instruments, you design the experiments.
1. Bacaback, R.G. The FASEB Journal. 2006. 20: 858-864.
2. Jacks, T. and Weingberg, A.R. Cell. 2002. 111(7): 923-925.
3. Kim, J. B. et al. Breast Cancer Research Treatment. 2004. 85(3):281-91.
4. Powell, C.A. et al. AJP: Cell Physiology. 2002. 282:C1557-C1565.
5. Roelofsen, J. et al. Journal of Biomechanics. 1995. 12: 1493-503.
6. Stegemann, J.P. and Nerem, R.M. Annals of Biomedical Engineering. 31(4): 391-402.
